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In a recent review published in the Nutrients Journal, researchers reviewed existing data on the pharmacological and biological effects of the components of Lycium ruthenicum Murray (LRM) fruits such as black goji berries.

Study: Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity. Image Credit: Tim Chow/Shutterstock.com

Background

The LRM plant, black wolfberry or black goji berry, thrives on China's Qinghai-Tibet plateau deserts. In traditional Chinese medicine, LRM is commonly used as an herbal remedy to treat cardiovascular disease, inflammation, weariness, and other medical issues.

According to research, LRM is high in functional phytochemicals such as polysaccharides and anthocyanins and has a wide range of pharmacological effects.

About the review

In the present review, researchers described the health benefits of consuming LRM based on studies retrieved from PubMed, Web of Science, and Google Scholar, published in English.

Nutritional contents and properties of black wolfberry

LRM fruits contain carbohydrates (67 g/100 g DW), dietary fiber (12 g/100 g DW), proteins (11.5 g/100 g DW), ash (6.3 g/100 g DW), fat (3.0 g/100 g DW), organic acids (4.7 g/100 g DW), vitamins (12.4 g/100 g DW), macroelements (22 g/100 g DW), microelements (129 g/100 g DW), carotenoids (1.5 g/100 g DW), anthocyanins (25 g/100 g DW), and polysaccharides (31 g/100 g DW).

The high tannin, phenol, and monomeric anthocyanin content in black wolfberry confers strong antioxidant properties. 

Constituents such as polysaccharides, anthocyanins, phenylpropanoid derivatives, polyphenolic glycosides, and seed oils confer anti-inflammatory, anti-aging, anti-cancer, organoprotective, anti-radiation, immunomodulatory, and tyrosine-inhibitory properties.

In addition, LRM consumption helps prevent fatigue, obesity, diabetes, and influenza virus infections.

Biological mechanisms underlying the pharmacological effects of black wolfberry

LRM fruit extracts, including anthocyanins, can lower tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, 2, 6, cyclooxygenase 2 (COX-2), and phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cell component p65 (p-NF-κBp65) levels.

Studies have also reported that LRM extracts can lower serum aging markers such as advanced glycation end products (AGEs), malondialdehyde (MDA), lipofuscin levels, and age-related gene (age-1) expression and improve amino acid metabolism.

In C57BL/6 mice, anthocyanins enhanced cognition by improving spatial learning, memory abilities, and cell viability.

In human breast cells, LRM fruit extracts have demonstrated antiproliferative activity and the activation of p21, p53, cyclin E, cyclin-dependent kinase 4 (CDK4), caspase3, and Bcl-2-associated X protein (Bax).

The levels of IL-4, IL-10, superoxide dismutase (SOD)-2,3, and catalase (CAT) can increase following LRM consumption.

In addition, LRM extracts can increase lifespan, oxidative resistance, irradiation tolerance, and the expression of genes such as daf-12,16, sirtuin-type domain-containing protein 2.1 (sir-2.1), c-Jun N-Terminal protein kinase 1 (jnk-1), and heat shock protein 16.2 (hsp-16.2).

Furthermore, LRM anthocyanins and fruit extracts are hepatoprotective. They can improve histological damage and reduce serum aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and Fas/Fas ligand (FasL) messenger ribonucleic acid (mRNA) expression levels. In addition, they can reduce the size of fat droplets in the liver.

Polysaccharides in LRM can reduce pancreatic cell proliferation, tumor size, tumor weight, Ki67, the cluster of differentiation 31 (CD31), phosphorylated glycogen synthase kinase 3β (p-GSK-3β), B cell lymphoma 2 (Bcl-2), phosphorylated protein kinase B (p-AKT), phosphorylated focal adhesion kinase (p-FAK), β-Catenin, p-P38, and caspase-3 and nine levels, and increase apoptosis. Polysaccharide intake can inhibit replication by arrest by resting phase (G0)-growth 1 phase (G1).

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In addition to anthocyanins and polysaccharides, polyphenolic glycosides confer neuroprotective properties by decreasing d-gal-induced neuronal apoptosis, Receptor for Advanced Glycation End-products (RAGE), beta-secretase enzyme 1 (BACE-1), amyloid beta protein 42 (Aβ42), glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), p-JNK, Bax/Bcl-2 ratio, and caspase-3 levels, and increasing cell viability and nuclear factor erythroid 2related factor 2 (Nrf2) expression. In addition, they can improve learning, memory impairments, memory, passive avoidance, cell viability, and morphologic changes.

LRM fruit extracts have demonstrated cardioprotective effects by decreasing creatine kinase-myocardial band (CK-MB) and LDH activities (amelioration of the myocardial histopathology), fiber necrosis, the number of inflammatory cells, and myocardial tissue (improved myocardial tissue damage).

LRM intake can protect against radiation injury by reducing caspase-3, P53, and apoptosis and increasing thymus index, spleen index, and deoxyribonucleic acid (DNA) content.

LRM extracts can modulate immune function by increasing B and T lymphocyte proliferation, macrophage phagocytosis, serum hemolysin formation, and anti-inflammatory cytokine levels.

LRM extracts and polysaccharides can lower fatigue by decreasing oxidative stress, blood urea nitrogen (BUN), triglyceride (TG), creatine phosphokinase (CPK), LDH, and MDA levels, increasing SOD, glucose, and glutathione peroxidase (GPx) levels, and TG mobilization, and preventing lipid oxidation.

LRM fruit extracts, seed oils, and phenylpropanoid derivatives confer anti-obesity and anti-diabetic properties by decreasing Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), fatty acid synthase (FASN), and sterol regulatory element-binding transcription factor 1 (SREBP1) expression, increasing Carnitine palmitoyltransferase (Cpt) levels, and inhibiting pancreatic lipase activity.

Based on the review findings, LRM, a nutritional supplement with numerous pharmacological properties, has potential as a preventative measure against chronic cardiometabolic and inflammatory diseases.

However, the safety and efficacy of LRM in humans are yet to be confirmed due to insufficient research at cellular and animal levels. Further clinical research is needed to verify the effectiveness of LRM in preventing these diseases.

Journal reference:

• Lee, H. S. and Choi, C.-I. () Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity, MDPI. doi: https://doi.org/10./nu. https://www.mdpi.com/-/15/19/

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Global Wolfberry Extract Market Report Market Size Split by Type (Capsules, Powder, Liquid, Others), by Application (Hospitals and Clinics, Individual Households)

"Global Wolfberry Extract market size was XX Million. Wolfberry Extract Industry compound annual growth rate (CAGR) will be XX% from till ."

Preview of Global Wolfberry Extract Market Revenue

Wolfberry Extract Market Size, CAGR and Industry Statistics

Base Year Historical Data Time Period- Forecast Period- Global Market Size

Country Market Size

North Americ Market Size

Europe Market Size

Asia Pacific Market Size

South America Market Size

Middle East and Africa Market Size

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Industry segmentation can be altred as per your needs. For example, we can proivde cross slipt between Capsules with Application, , additional country analysis, volume/consumption data, etc.

Wolfberry Extract Market Report Scope

Market Split by Type

• Capsules
• Powder
• Liquid
• Others

Market Split by Application

• Hospitals and Clinics
• Individual Households

List of Competitors

• SwansonUS
• Xiu ZhengCN
• Piping Rock Health ProductsUS
• Doctor's BestUS
• AyurishIN
• Confidential Data
• Access The Paid Version
• Data Hidden

Regional Analysis

• North America
• Europe
• Asia-Pacific
• South America
• Middle East and Africa

Country Analysis

• North America (United States, Canada, Mexico)
• Europe (United Kingdom, France, Germany, Italy, Russia, Spain, Sweden, Denmark, Netherlands, Switzerland, Belgium, Rest of Europe)
• Asia-Pacific (China, Japan, Korea, India, Australia, Philippines, Singapore, Malaysia, Thailand, Indonesia, Rest of APAC)
• South America (Brazil, Argentina, Colombia, Peru, Chile, Rest of South America)
• Middle East and Africa (Saudi Arabia, Turkey, Nigeria, UAE, Egypt, South Africa, GCC Countries, Rest of MEA)

Key Qualitative Information Covered

• Market Trends
• Market Drivers
• Market Restraints
• Market Opportunity
• Market Attractiveness Analysis
• COVID&#;19 Impact and Recovery Analysis
• PESTEL Analysis
• Porter&#;s Five Forces Analysis
• Product Life Cycle
• Industrial Chain Analysis
• Patent Analysis
• ESG Analysis

Report scope is customizable as we have a huge database of Wolfberry Extract industry. We can deliver an exclusive report Edition/Consultation as per your data requirements. Request for your Free Sample Pages.

Wolfberry Extract Market is Segmented as below. Particular segment of your interest can be provided without any additional cost. Download the Sample Pages!

Wolfberry Extract Market Report Description

Cognitive Market Research has recently published the 7th edition of Wolfberry Extract Market Report . It provides majorly two types of information qualitative and quantitative. In terms of quantitative data, current market size, competitors market shares, market forecast, and other industry updates with respect to global, regional, and country levels. Whereas qualitative data, unveils market drivers, restraints, current trends, opportunities, and more. To know more, we encourage you to order the free sample pages.

Market Dynamics such as Drivers, Restraints, Opportunities, Trends data

Wolfberry Extract Industry Dynamics

• Market Drivers of Wolfberry Extract: The key factors which influence the overall sales demand for Wolfberry Extract Industry in a positive way. Market drivers help you understand the impact on market growth. With this information you can predict how said market is likely to grow in the coming year. 
• Market Restraints of Wolfberry Extract: Restraints are the negative factors which hinder the market growth and development in the near future. Some of the restraining factors including strict government regulations, supply chain disruptions, changing consumer preference are affecting the market growth in the near future. For example, the outburst of COVID-19 affected the most of the industries. Restraining factors are important to analyse on account of companies can develop strategies to overcome their negative impact on the growth of the market.
• Market Opportunities of Wolfberry Extract: Market opportunities are expected to open up growth window for the new entrants in the market. It helps to understand unmet needs or an untapped potential in the market.
• Market Trends of Wolfberry Extract: (This information will be part of the paid report version.)

We have various report editions of Wolfberry Extract Market, hence please contact our sales team and author directly to obtain/purchase a desired Edition eg, Global Edition, Regional Edition, Country Specific Report Edition, Company Profiles, Forecast Edition, etc. Request for your Free Sample PDF/Online Access.

Top Companies in Wolfberry Extract Market

Competitive Landscape includes company profiling of the key manufacturers listed below. It also provides the key developments such as new product launches, expansion, mergers & acquisitions, partnerships, agreements, joint ventures, business overview, key strategies and financial analysis associated with the key players. Strategy implemented to overcome the COVID-19 Impact will be discussed in the report scope. Key players Financials includes Revenue (USD Million), Gross Margin (%) and Market Share (%) (- ), S.W.O.T Analysis, (To read more request the sample pages Or speak to analyst/author directly).

Top Companies Market Share in Wolfberry Extract Industry: (In no particular order of Rank)

• SwansonUS
• Xiu ZhengCN
• Piping Rock Health ProductsUS
• Doctor's BestUS
• AyurishIN
• Confidential Data
• Access The Paid Version
• Data Hidden

*List of Second Tier Companies, List of Third Tier/ Start-up Companies (Inquire with sales executive)

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Wolfberry Extract Market Regional Analysis

Region and country analysis section of Wolfberry Extract Industry Analysis has been segmented into 5 major region such as North America, Europe, Asia Pacific, Middle East & Africa ,and Latin America (along with respective major contributing countries) and provides the revenue share, current trends.

The base years considered for all the estimations by analyzing trends and growth rate will help you gain an in-depth understanding of the conclusions provided in this report. This report also includes figures, graphs, pie charts, tables and bar graphs that explain the data analysis based on current trends at the country level as well as key regions. This research report also focuses on assessing factors such as profit, product price, capacity, production, supply demand market growth rate along with others to create a clear picture on the future prospects of Wolfberry Extract market.

The current report Scope analyzes Wolfberry Extract Market on 5 major region Split (In case you wish to acquire a specific region edition (more granular data) or any country Edition data then please write us on

• North America (United States, Canada, Mexico)
• Europe (United Kingdom, France, Germany, Italy, Russia, Spain, Sweden, Denmark, Netherlands, Switzerland, Belgium)
• Asia-Pacific (China, Japan, Korea, India, Australia, Philippines, Singapore, Malaysia, Thailand, Indonesia, Rest of APAC)
• South America (Brazil, Argentina, Colombia, Peru, Chile, Rest of South America)
• Middle East and Africa (Saudi Arabia, Turkey, Nigeria, UAE, Egypt, South Africa, GCC Countries, Rest of MEA)

Wolfberry Extract Market Share (%) by Region (-)

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Wolfberry Extract Market Analysis

Global Wolfberry Extract Market Report Edition talks about crucial market insights with the help of segments and sub-segments analysis. In this section, we reveal an in-depth analysis of the key factors influencing Wolfberry Extract Industry growth. Wolfberry Extract market has been segmented with the help of its Type, Application , and others. Wolfberry Extract market analysis helps to understand key industry segments, and their global, regional, and country-level insights. Furthermore, this analysis also provides information pertaining to segments that are going to be most lucrative in the near future and their expected growth rate and future market opportunities. The report also provides detailed insights into factors responsible for the positive or negative growth of each industry segment.

Type Segment Analysis of Wolfberry Extract Market

Based on present and future trends, the market size is estimated from to . Moreover, study also provides quantitative and qualitative analysis of each type to understand the driving factors for the fastest growing type segment for Wolfberry Extract market.

Type of Wolfberry Extract analyzed in this report are as follows:

• Capsules
• Powder
• Liquid
• Others

Wolfberry Extract Market Share (%) by Type in -

The above Chart is for representative purposes and does not depict actual sale statistics. Access/Request the quantitative data to understand the trends and dominating segment of Wolfberry Extract Industry. Request a Free Sample PDF!

Application Segment Analysis of Wolfberry Extract Market

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends and opportunities for each application of Wolfberry Extract from to . This will also help to analyze the demand for Wolfberry Extract across different end-use industries. Our research team will also help acquire additional data such as Value Chain, Patent analysis, Company Evaluation Quadrant (Matrix), and much more confidential analysis and data insights.

Some of the key Application of Wolfberry Extract are:

• Hospitals and Clinics
• Individual Households

Wolfberry Extract Market Share (%) by Application in -

The above Graph is for representation purposes only. This chart does not depict actual Market share. Please purchase the Wolfberry Extract market report Edition by contacting our team.

Author's Detail

Manjiri Kanhere

Manjiri Kanhere

Senior Research Associate at Cognitive Market Research

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Profile

Manjiri Kanhere is an experienced market researcher focused on the Pharma & Healthcare industry. With over 3+ years of experience, She has worked with major pharmaceutical companies and healthcare providers, helping them to understand market trends, identify new business opportunities, and develop effective sales & marketing strategies. Her expertise lies in the ability to analyze complex data sets and deliver insights that drive business decisions. At Cognitive Market Research, she handles the market research related to Pharma and healthcare industry.

Bio :

Manjiri Kanhere is an experienced market researcher focused on the Pharma & Healthcare industry. With over three years of experience, She has worked with major pharmaceutical companies and healthcare providers, helping them to understand market trends, identify new business opportunities, and develop effective sales & marketing strategies.

In her current role, Manjiri handles the market research related to Pharma and healthcare industry. Her passion lies in utilizing innovative approaches to distill complex information into strategic insights that empower organizations to make informed decisions.Manjiri remains an invaluable asset in the dynamic landscape of market research.

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Author's Conclusion

Our study will explain complete manufacturing process along with major raw materials required to manufacture end-product. This report helps to make effective decisions determining product position and will assist you to understand opportunities and threats around the globe.

The Global Wolfberry Extract Market is witnessing significant growth in the near future.

In , the Capsules segment accounted for noticeable share of global Wolfberry Extract Market and is projected to experience significant growth in the near future.

The Hospitals and Clinics segment is expected to expand at the significant CAGR retaining position throughout the forecast period.

Some of the key companies SwansonUS, Piping Rock Health ProductsUS and others are focusing on its strategy building model to strengthen its product portfolio and expand its business in the global market.